Trichothecenes (Type A & B)
Also known as: T-2 toxin · HT-2 toxin · Deoxynivalenol · DON · Vomitoxin · Diacetoxyscirpenol · DAS
Overview
A large family of sesquiterpenoid mycotoxins produced primarily by Stachybotrys chartarum (black mold), Fusarium, and Trichothecium species. Trichothecenes are among the most potent protein synthesis inhibitors known and are a primary toxin of concern in water-damaged buildings. They are highly stable, persist on building materials, and are readily inhaled on mold fragments and dust particles. PBMC-based testing detects systemic absorption that serum testing often misses.
Primary Sources
Inhalation in water-damaged buildings with Stachybotrys chartarum (black mold) or Fusarium growth; damp drywall, ceiling tiles, and HVAC systems; contaminated grain, corn, and wheat.
Health Effects
Profound immunosuppression, hemorrhagic syndrome, severe fatigue, cognitive impairment (brain fog), mucous membrane irritation, nausea, dermatitis, CIRS, and potential link to pulmonary hemorrhage in infants.
Detection Method
This toxin is detected and quantified using HRMS (LC or GC) analysis of isolated PBMCs. The intracellular accumulation of this compound in lymphocytes and monocytes provides a more accurate reflection of chronic systemic burden than conventional serum or urine testing.