Sterigmatocystin
Also known as: STE · STG
Overview
A polyketide mycotoxin produced by Aspergillus versicolor — one of the most common molds found in water-damaged buildings. Sterigmatocystin is a biosynthetic precursor to aflatoxin B1 and shares its carcinogenic mechanism of DNA adduct formation. It is frequently detected in building dust and air samples from damp environments and is a key biomarker in WDB assessments.
Primary Sources
Inhalation in water-damaged buildings with Aspergillus versicolor growth; damp building materials (plasterboard, chipboard, wallpaper); contaminated grain and animal feed.
Health Effects
Hepatotoxicity, nephrotoxicity, classified as a possible human carcinogen (IARC Group 2B), DNA adduct formation, immune dysregulation, and chronic respiratory inflammation from inhalation.
Detection Method
This toxin is detected and quantified using HRMS (LC or GC) analysis of isolated PBMCs. The intracellular accumulation of this compound in lymphocytes and monocytes provides a more accurate reflection of chronic systemic burden than conventional serum or urine testing.