SiliconeHRMS (LC or GC)
Silicone Oligomers & Siloxanes
Also known as: D4 · D5 · D6 · PDMS degradation products
Overview
Low-molecular-weight cyclic and linear siloxanes released from silicone implants, personal care products, and industrial sources. PBMC-based testing is uniquely suited to detect systemic silicone exposure from implants.
Primary Sources
Silicone breast implants, medical devices, personal care products, industrial lubricants.
Health Effects
Immune activation (ASIA syndrome), autoimmune conditions, breast implant illness, inflammatory responses.
Detection Method
This toxin is detected and quantified using HRMS (LC or GC) analysis of isolated PBMCs. The intracellular accumulation of this compound in lymphocytes and monocytes provides a more accurate reflection of chronic systemic burden than conventional serum or urine testing.